Leukotriene Biosynthesis
Gene co-expression module in Lymphatic endothelial
| Category | Lipid metabolism |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes include SNCG (synuclein gamma, expressed in vascular endothelium under stress), LTC4S (leukotriene C4 synthase, key enzyme in cysteinyl leukotriene biosynthesis from arachidonic acid), APOLD1 (apolipoprotein L domain containing 1, vascular stress/permeability response), THBD (thrombomodulin, anticoagulant endothelial surface protein), EMP1 (epithelial membrane protein 1, barrier/signaling), ADIRF (adipogenesis regulatory factor), ITM2A (integral membrane protein 2A), and AKAP12 (A-kinase anchoring protein 12, barrier function scaffold). LTC4S is the defining enzyme for leukotriene C4 synthesis, a potent lipid mediator of inflammation and vascular permeability. The module is significantly decreased with treatment, consistent with resolution of inflammatory lipid mediator production. THBD and APOLD1 add vascular tone/permeability context.
Genes
ADIRF, AKAP12, APOLD1, EMP1, ITM2A, LTC4S, PLAC9, SNCG, THBD
Most correlated modules
- Oxidative Stress Protection · correlation 0.81
- ECM Remodeling TGFb · correlation 0.76
- Lymphatic Vascular Stability · correlation 0.73
- Endothelial Identity · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.