ECM Remodeling TGFb
Gene co-expression module in Lymphatic endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include LTBP4 (latent TGF-β binding protein, TGF-β pathway), TNXB (tenascin-X, ECM glycoprotein), CHRDL1 (chordin-like 1, BMP antagonist), CCDC80 (ECM-associated), LAMB2 (laminin beta-2, basement membrane), HS3ST1 (heparan sulfate 3-O-sulfotransferase, ECM modification), LAYN (layilin, hyaluronan receptor), NT5E (CD73, ectonucleotidase producing adenosine), and ECSCR (endothelial cell-specific chemotaxis regulator). The strong ECM/basement membrane theme combined with TGF-β pathway components (LTBP4, CHRDL1) and the endothelial marker ECSCR suggests a program of ECM remodeling and TGF-β signaling in lymphatic endothelial cells. NT5E/CD73 adds immune-modulatory capacity. This module likely reflects a quiescent lymphatic endothelial state with active ECM maintenance.
Genes
CCDC80, CCND1, CHRDL1, CRIP1, CTSH, ECSCR, HS3ST1, IARS2, LAMB2, LAYN, LRATD1, LTBP4, NT5E, SLC24A1, SYNM, TNXB, UCP2
Most correlated modules
- Oxidative Stress Protection · correlation 0.90
- Caveolae Cytoskeletal · correlation 0.88
- Lymphatic EC Identity · correlation 0.85
- Lymphatic Vascular Stability · correlation 0.79
- Leukotriene Biosynthesis · correlation 0.76
- Septin Cytoskeleton · correlation 0.75
- Lymphatic Valve Formation · correlation 0.75
- Endothelial Identity · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.