APOLD1 — Apolipoprotein L domain containing 1
APOLD1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APOLD1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Regulatory T cell Immune regulation | ACTA2, ATP13A3, CARD16, CD27, CD79B, DNAH8, FAM184A, HS3ST3B1 +7 more | View in SCUBA |
| Endothelial | Glucocorticoid Response Endothelial cell development | DENND3, DPYSL2, JAM3, KLF11, KLF9, MFSD6, NDRG1, PHLPP1 +8 more | View in SCUBA |
| Lymphatic endothelial | Leukotriene Biosynthesis Lipid metabolism | ADIRF, AKAP12, EMP1, ITM2A, LTC4S, PLAC9, SNCG, THBD | View in SCUBA |
| Pericytes | EMT-like Remodeling ECM remodeling | B3GNT5, C2CD4B, CFAP20, FAM43A, INSIG1, LDLR, RALGDS, RND1 +2 more | View in SCUBA |
About the gene
| Synonyms | DKFZP434F0318, FLJ25138 |
|---|---|
| Chromosome | 12: 12725917-12829975 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Is a modulator of endothelial barrier permeability, required for proper organization of endothelial cell-cell junctions and cytoskeleton. It also plays a role in the modulation of secretory autophagy. May affect blood-brain barrier permeability.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.