Oxidative Stress Protection
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 19 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
Top hub genes include MGST2 (microsomal glutathione S-transferase, oxidative stress/detox), CAVIN2 (caveolae biogenesis), SELENOP (selenium transport, antioxidant), ALDH2 (aldehyde dehydrogenase, oxidative stress protection), HYAL2 (hyaluronidase, ECM), and CRACR2B (calcium release-activated channel regulator). The module is significantly downregulated with inflammation in CD, suggesting these are homeostatic protective programs suppressed during disease. CCL21 (lymphatic chemokine) confirms lymphatic context. TNFSF12 (TWEAK) adds an inflammatory tone. The dominant theme across hub genes is antioxidant defense and detoxification, consistent with a lymphatic endothelial oxidative stress protection program that is lost during intestinal inflammation.
Genes
ALDH2, ANAPC16, BCL7C, CAVIN2, CCL21, CD320, CRACR2B, FXYD6, GUSB, HMGN3, HYAL2, ITGB1BP1, KANK3, MGST2, SELENOP, SH3BGRL, SNX2, TFF3, TNFSF12
Most correlated modules
- Lymphatic EC Identity · correlation 0.94
- Caveolae Cytoskeletal · correlation 0.94
- ECM Remodeling TGFb · correlation 0.90
- Fatty Acid Oxidation · correlation 0.89
- Metabolic Housekeeping · correlation 0.88
- Lymphatic Vascular Stability · correlation 0.85
- Mitochondrial Translation · correlation 0.85
- Mitochondrial OxPhos Complex · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.