Lymphatic Vascular Stability
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
Key hub genes include SELENON (ER-resident selenoprotein involved in redox regulation and ER stress), S1PR1 (sphingosine-1-phosphate receptor 1, critical for lymphocyte egress and lymphatic endothelial function), ROBO4 (roundabout guidance receptor 4, vascular stability and integrity), SERPING1 (C1-inhibitor, complement/coagulation regulation), GJA1 (connexin 43, gap junctions), MAF (transcription factor for lymphatic/vascular differentiation), IGFBP4 (IGF signaling modulator), and WFS1 (ER stress/Wolfram syndrome gene). S1PR1 and ROBO4 are well-established lymphatic vascular stability genes. The module shows positive delta with treatment, suggesting restoration of a mature lymphatic state. The combination of S1PR1, ROBO4, SERPING1, and MAF points to a lymphatic vascular maturation and stability program.
Genes
GJA1, GLT8D2, HIC1, HSD17B12, IGFBP4, KCTD12, MAF, ROBO4, S1PR1, SELENON, SERPING1, SHC1, SLC27A3, TRIOBP, WFS1
Most correlated modules
- Endothelial Identity · correlation 0.87
- Lymphatic Valve Formation · correlation 0.86
- Anticoagulant Barrier · correlation 0.85
- Oxidative Stress Protection · correlation 0.85
- Lymphangiogenesis ECM · correlation 0.84
- ECM Remodeling TGFb · correlation 0.79
- Septin Cytoskeleton · correlation 0.76
- Vascular Lumen Formation · correlation 0.74
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.