THBD — Thrombomodulin
THBD belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
THBD's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Glucocorticoid Response Endothelial cell development | APOLD1, DENND3, DPYSL2, JAM3, KLF11, KLF9, MFSD6, NDRG1 +8 more | View in SCUBA |
| Fibroblasts | Heparan Sulfate Remodeling ECM remodeling | ALDH1A3, COL12A1, FAM171B, FANCC, FHOD3, GREB1, HS6ST1, JMJD1C +11 more | View in SCUBA |
| Lymphatic endothelial | Leukotriene Biosynthesis Lipid metabolism | ADIRF, AKAP12, APOLD1, EMP1, ITM2A, LTC4S, PLAC9, SNCG | View in SCUBA |
| Macrophages | Hypoxia Stress Response Stress | ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more | View in SCUBA |
| Pericytes | Arterial Notch Signaling Developmental | BCL6B, CYTH1, DLL4, EFNB2, HEY1, MSX1, NEDD9, PNP +1 more | View in SCUBA |
About the gene
| Synonyms | BDCA-3, CD141, THRM |
|---|---|
| Chromosome | 20: 23045633-23049672 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Candidate cardiovascular disease genes, CD markers, Disease related genes, Human disease related genes, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Blood coagulation, Hemostasis |
Function
Endothelial cell receptor that plays a critical role in regulating several physiological processes including hemostasis, coagulation, fibrinolysis, inflammation, and angiogenesis. Acts as a cofactor for thrombin activation of protein C/PROC on the surface of vascular endothelial cells leading to initiation of the activated protein C anticoagulant pathway. Also accelerates the activation of the plasma carboxypeptidase B2/CPB2, which catalyzes removal of C-terminal basic amino acids from its substrates including kinins or anaphylatoxins leading to fibrinolysis inhibition. Plays critical protective roles in changing the cleavage specificity of protease-activated receptor 1/PAR1, inhibiting endothelial cell permeability and inflammation (By similarity). Suppresses inflammation distinctly from its anticoagulant cofactor activity by sequestering HMGB1 thereby preventing it from engaging cellular receptors such as RAGE and contributing to the inflammatory response.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.