Endothelial Identity
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
ICAM2 (intercellular adhesion molecule 2, constitutively expressed on endothelial/lymphatic cells) and PROCR (protein C receptor, endothelial anticoagulant receptor) are canonical endothelial/lymphatic identity markers and are the top hubs. CLU (clusterin, complement regulation and cytoprotection), SCARA3 (scavenger receptor A3), TNFSF10 (TRAIL, apoptosis ligand with immune-modulatory roles), LY6E (interferon-stimulated gene), and PSIP1 (chromatin regulator) round out a module reflecting endothelial identity with immune interaction capacity. ARL6IP5 is involved in glutathione transport. This module captures a lymphatic/endothelial identity program with leukocyte interaction features.
Genes
ARL6IP5, CLU, ICAM2, LY6E, NTS, NUCB1, PLAAT4, PROCR, PSIP1, SCARA3, TNFSF10
Most correlated modules
- Metabolic Housekeeping · correlation 0.86
- Mitochondrial Translation · correlation 0.82
- Vascular Lumen Formation · correlation 0.81
- ER-Lysosomal Processing · correlation 0.80
- Lymphatic Valve Identity · correlation 0.77
- Innate Immune Activation · correlation 0.77
- Oxidative Stress Protection · correlation 0.76
- GIMAP mediated permeability · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.