Cytoskeletal Housekeeping
Gene co-expression module in Lymphatic endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 12 genes have a known function matching the annotation |
Why this annotation
YWHAB (14-3-3 beta, signal scaffolding), ARPC5 (Arp2/3 actin nucleation complex), DYNLT1 (dynein light chain, microtubule motor), and PPP1CA (protein phosphatase 1) form a cytoskeletal/signaling housekeeping core. CD81 is a tetraspanin involved in membrane organization. TMED9 and TMBIM6 contribute vesicle trafficking and anti-apoptotic functions. CNBP is a zinc-finger transcriptional regulator. The module is broadly expressed with high coherence, consistent with constitutive cytoskeletal maintenance. Neighbor context with M31 (adhesion) and M73 (actin/glycolysis) supports a cytoskeletal housekeeping theme.
Genes
ARPC5, C11orf58, CD81, CNBP, DYNLT1, GYPC, PPP1CA, SYPL1, TMBIM6, TMED9, TMEM50A, YWHAB
Most correlated modules
- 20S Proteasome Core · correlation 0.93
- Actomyosin Cytoskeleton · correlation 0.88
- Mitochondrial OxPhos Complex · correlation 0.88
- Oxidative Stress Response · correlation 0.87
- MHC-I Antigen Presentation · correlation 0.86
- Mitochondrial OxPhos Complex · correlation 0.85
- Glycolytic Housekeeping · correlation 0.82
- GIMAP mediated permeability · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.