Actomyosin Cytoskeleton
Gene co-expression module in Lymphatic endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes: SUMO2 (SUMOylation, protein modification), EDF1 (transcriptional coactivator, stress response), CD63 (tetraspanin, lysosome/exosome marker), SRP14 (signal recognition particle, ER targeting), COX4I1 (cytochrome c oxidase subunit, mitochondrial), MYL6/MYL12A/MYL12B (myosin light chains, actomyosin), CFL1 (cofilin, actin dynamics), RAC1 (Rho GTPase, actin/migration), GABARAPL2 (autophagy, LC3 family), CHCHD2 (mitochondrial intermembrane space), SERF2 (amyloid modulator), HINT1 (histidine triad, signaling), LGALS3 (galectin-3, inflammation/adhesion), PFN1 (profilin, actin polymerization), BRI3 (apoptosis regulator). The module is dominated by actomyosin cytoskeletal genes (MYL6, MYL12A, MYL12B, CFL1, RAC1, PFN1) alongside autophagy (GABARAPL2), mitochondrial (COX4I1, CHCHD2), and SUMOylation (SUMO2). The cytoskeletal component is the most coherent theme. Neighbor context: sits near housekeeping/translation modules; the cytoskeletal program here likely reflects basal lymphatic endothelial cell motility and shape maintenance.
Genes
BRI3, CD63, CFL1, CHCHD2, COX4I1, EDF1, GABARAPL2, HINT1, LGALS3, MYL12A, MYL12B, MYL6, PFN1, RAC1, SERF2, SRP14, SUMO2
Most correlated modules
- 20S Proteasome Core · correlation 0.92
- MHC-I Antigen Presentation · correlation 0.91
- Mitochondrial OxPhos Complex · correlation 0.90
- Translation Elongation · correlation 0.89
- mRNA Translation Regulation · correlation 0.88
- Cytoskeletal Housekeeping · correlation 0.88
- Oxidative Phosphorylation · correlation 0.83
- Protein Quality Control · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.