Mitochondrial OxPhos Complex
Gene co-expression module in Lymphatic endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 15 genes have a known function matching the annotation |
Why this annotation
This module mixes several programs. NDUFAB1, NDUFS6, NDUFB2, NDUFC1, NDUFA12, UQCR10 are mitochondrial Complex I/III subunits (OxPhos). LSM3 and SNRPD2 are spliceosomal snRNP components (RNA processing). MRPL51 and MRPS21 are mitochondrial ribosomal proteins. BRK1 is an actin nucleation factor. AP2M1 is a clathrin adaptor. ANAPC11 is an APC/C ubiquitin ligase subunit. The module is coherent but mixed; the dominant signal by gene count is mitochondrial/OxPhos, with a secondary RNA processing component. Given the neighborhood context of OxPhos modules, the mitochondrial program is primary, but the spliceosomal genes suggest a housekeeping admixture.
Genes
ANAPC11, AP2M1, BRK1, LSM3, MRPL51, MRPS21, NDUFA12, NDUFAB1, NDUFB2, NDUFC1, NDUFS6, SNRPD2, SRI, TCEAL4, UQCR10
Most correlated modules
- Oxidative Stress Response · correlation 0.97
- Mitochondrial OxPhos Complex · correlation 0.95
- Housekeeping Mixed · correlation 0.94
- Mitochondrial OxPhos Complex · correlation 0.92
- Metabolic Housekeeping · correlation 0.91
- Oxidative Phosphorylation · correlation 0.90
- Fatty Acid Oxidation · correlation 0.89
- Cytoskeletal Housekeeping · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.