Glycolytic Housekeeping
Gene co-expression module in Lymphatic endothelial
| Category | Housekeeping |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
ENO1 (enolase, glycolysis), PGAM1 (phosphoglycerate mutase, glycolysis), and EIF2S2 (eIF2 subunit, translation initiation) are core metabolic/housekeeping enzymes. CAP1 regulates actin dynamics. DYNC1I2 is a dynein intermediate chain. DPYSL2 (CRMP2) is a cytoskeletal/axon guidance protein. CANX (calnexin) is an ER chaperone. CALCOCO2 mediates selective autophagy. TMX4 is an ER oxidoreductase. GIMAP8 (weak membership) bridges to the T-cell contamination module M15. The dominant theme is glycolytic enzyme expression combined with cytoskeletal components — a general metabolic housekeeping program.
Genes
CALCOCO2, CANX, CAP1, DPYSL2, DYNC1I2, EIF2S2, ENO1, GIMAP8, PGAM1, TMX4
Most correlated modules
- ER-Lysosomal Processing · correlation 0.86
- Antigen Presentation IFN · correlation 0.83
- Integrin Focal Adhesion · correlation 0.83
- Cytoskeletal Housekeeping · correlation 0.82
- GIMAP mediated permeability · correlation 0.76
- Vascular Lumen Formation · correlation 0.75
- Septin Cytoskeleton · correlation 0.70
- 20S Proteasome Core · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.