Mitochondrial OxPhos Complex
Gene co-expression module in Lymphatic endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 15 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
This module is dominated by cytochrome c oxidase (Complex IV) subunits: COX8A, COX6C, COX6B1, COX7A2, COX6A1, plus NDUFB4, NDUFA1, NDUFB5, NDUFS5 (Complex I subunits). TMEM258 and OST4 are ER/oligosaccharyltransferase complex components. TRMT112 is a methyltransferase activator. DAD1 is an anti-apoptotic protein and OST complex subunit. UBL5 is a ubiquitin-like protein. The dominant signal is clearly mitochondrial oxidative phosphorylation (Complex I and IV subunits), consistent with the neighborhood. OST4 and DAD1 suggest a minor ER protein processing component.
Genes
COX6A1, COX6B1, COX6C, COX7A2, COX8A, DAD1, NDUFA1, NDUFB4, NDUFB5, NDUFS5, OST4, PTMS, TMEM258, TRMT112, UBL5
Most correlated modules
- Housekeeping Mixed · correlation 0.94
- Mitochondrial OxPhos Complex · correlation 0.92
- Oxidative Phosphorylation · correlation 0.92
- Oxidative Stress Response · correlation 0.91
- Actomyosin Cytoskeleton · correlation 0.90
- Mitochondrial OxPhos Complex · correlation 0.89
- Oxidative Phosphorylation · correlation 0.87
- 20S Proteasome Core · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.