MHC-I Antigen Presentation
Gene co-expression module in Lymphatic endothelial
| Category | Immune regulation |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes: HLA-C, HLA-A, HLA-B, HLA-E — four MHC class I molecules. PSME1 (proteasome activator PA28α, immunoproteasome), PSMB8 (β5i, immunoproteasome catalytic subunit). OAZ1 (ornithine decarboxylase antizyme, polyamine metabolism), TUBB (tubulin beta), RHOC (Rho GTPase), PPP1R14B (protein phosphatase inhibitor), ATP6V1F (vacuolar ATPase). The module is clearly anchored by MHC class I antigen presentation machinery (HLA-A/B/C/E + PSME1 + PSMB8). This is a canonical MHC-I / immunoproteasome antigen presentation module. Neighbor context: adjacent to constitutive proteasome (M55) and proteasome assembly (M42), forming a proteasome-to-immunoproteasome-to-MHC-I antigen presentation axis.
Genes
ATP6V1F, HLA-A, HLA-B, HLA-C, HLA-E, OAZ1, PPP1R14B, PSMB8, PSME1, RHOC, TUBB
Most correlated modules
- Actomyosin Cytoskeleton · correlation 0.91
- 20S Proteasome Core · correlation 0.89
- Cytoskeletal Housekeeping · correlation 0.86
- Proteasome Assembly · correlation 0.86
- mRNA Translation Regulation · correlation 0.85
- Translation Elongation · correlation 0.82
- Oxidative Stress Response · correlation 0.80
- Mitochondrial OxPhos Complex · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.