20S Proteasome Core
Gene co-expression module in Lymphatic endothelial
| Category | Protein processing & ER |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes: PSMB5, PSMB6, PSMA7, PSMB3, PSMB1, PSMB2 — six proteasome beta and alpha subunits of the 20S core proteasome. RBX1 (RING-box protein, SCF E3 ubiquitin ligase), PRDX1 (peroxiredoxin, antioxidant), NOP10 (H/ACA snoRNP, ribosome biogenesis), ERH (enhancer of rudimentary homolog, RNA processing), CLTA (clathrin light chain, endocytosis), ATP6V0E1 (vacuolar ATPase), DBI (diazepam binding inhibitor, lipid/steroid metabolism). The module is strongly anchored by six 20S proteasome subunits, making this a canonical constitutive proteasome module. delta_inflammation_CD is significantly negative (sig.), consistent with proteasome activity being relatively suppressed in inflammation. Neighbor context: directly neighbors M42 (proteasome assembly/maturation) and M56 (immunoproteasome + MHC-I), forming a coherent proteasome cluster.
Genes
ATP6V0E1, CLTA, DBI, ERH, NOP10, PRDX1, PSMA7, PSMB1, PSMB2, PSMB3, PSMB5, PSMB6, RBX1
Most correlated modules
- Cytoskeletal Housekeeping · correlation 0.93
- Actomyosin Cytoskeleton · correlation 0.92
- MHC-I Antigen Presentation · correlation 0.89
- Proteasome Assembly · correlation 0.89
- Mitochondrial OxPhos Complex · correlation 0.87
- Oxidative Stress Response · correlation 0.85
- Mitochondrial OxPhos Complex · correlation 0.84
- mRNA Translation Regulation · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.