Oxidative Stress Response
Gene co-expression module in Lymphatic endothelial
| Category | Stress |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 10 genes have a known function matching the annotation |
Why this annotation
GADD45GIP1 (GADD45 gamma interacting protein 1) is a mitochondrial protein involved in oxidative stress response. ATOX1 is a copper chaperone involved in antioxidant defense. GSTP1 is glutathione S-transferase pi, a key detoxification/stress response enzyme. FKBP1A is an immunophilin/chaperone. AP2S1 is a clathrin adaptor. RABAC1 (Rab acceptor 1) is involved in vesicle trafficking. VAMP5 is a SNARE protein. SH3BGRL3 is a thioredoxin-like protein with redox function. C4orf3 and APRT are metabolic enzymes. The dominant theme is cellular stress response and detoxification (GADD45GIP1, ATOX1, GSTP1, SH3BGRL3), consistent with a housekeeping/stress program in lymphatic endothelial cells.
Genes
AP2S1, APRT, ATOX1, C4orf3, FKBP1A, GADD45GIP1, GSTP1, RABAC1, SH3BGRL3, VAMP5
Most correlated modules
- Mitochondrial OxPhos Complex · correlation 0.97
- Housekeeping Mixed · correlation 0.94
- Mitochondrial OxPhos Complex · correlation 0.92
- Mitochondrial OxPhos Complex · correlation 0.91
- Oxidative Phosphorylation · correlation 0.89
- GIMAP mediated permeability · correlation 0.87
- Cytoskeletal Housekeeping · correlation 0.87
- Metabolic Housekeeping · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.