Integrin Focal Adhesion
Gene co-expression module in Lymphatic endothelial
| Category | migration & adhesion |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes ITGB1 (integrin beta-1), TLN1 (talin-1), and LIMS1 (PINCH protein) form the canonical integrin-linked kinase (ILK) focal adhesion complex. SEC62 and PDIA3 contribute ER/protein folding functions, ATP5PB/ATP5F1A are mitochondrial ATP synthase subunits, and NUCKS1/DEK are chromatin-associated. Despite the mixed composition, the integrin adhesion triad (ITGB1, TLN1, LIMS1) with strong/core membership scores dominates the module identity. Uniform expression across subsets is consistent with constitutive adhesion signaling in lymphatic endothelial cells.
Genes
APLP2, ATP5F1A, ATP5PB, DEK, ITGB1, LIMS1, MCFD2, NPC2, NUCKS1, PDIA3, RWDD1, SEC62, TLN1
Most correlated modules
- ER-Lysosomal Processing · correlation 0.91
- Mitochondrial Translation · correlation 0.88
- Metabolic Housekeeping · correlation 0.85
- Fatty Acid Oxidation · correlation 0.83
- Glycolytic Housekeeping · correlation 0.83
- Mitochondrial OxPhos Complex · correlation 0.82
- GIMAP mediated permeability · correlation 0.82
- Septin Cytoskeleton · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.