Vascular Lumen Formation
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
RASIP1 is a Ras-interacting protein essential for vascular lumen formation and endothelial cell polarity. CD47 is a ubiquitous 'don't-eat-me' signal also involved in endothelial cell survival and vascular homeostasis. ANXA4 (annexin A4) participates in membrane organization and Ca2+ signaling. MTDH/AEG-1 is involved in cell survival and adhesion. STAT1 has moderate membership and may reflect peripheral inflammatory signaling. LMAN1 is an ER-Golgi cargo receptor. GINM1 and BLCAP are less characterized. The RASIP1-CD47 axis points to vascular lumen formation and endothelial homeostasis, consistent with the endothelial development neighborhood.
Genes
ANXA4, BLCAP, CD47, GINM1, LMAN1, MTDH, RASIP1, STAT1
Most correlated modules
- Innate Immune Activation · correlation 0.91
- Endothelial Identity · correlation 0.88
- ER-Lysosomal Processing · correlation 0.84
- Lymphatic Specification · correlation 0.82
- Endothelial Identity · correlation 0.81
- Septin Cytoskeleton · correlation 0.79
- Anticoagulant Barrier · correlation 0.77
- Glycolytic Housekeeping · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.