ER-Lysosomal Processing
Gene co-expression module in Lymphatic endothelial
| Category | Protein processing & ER |
|---|---|
| Genes | 11 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes GRN (lysosomal granulin), LAMP1 (lysosomal membrane protein), CTSD (cathepsin D lysosomal protease), PSAP (prosaposin, lysosomal sphingolipid activator), OS9 (ER-associated degradation lectin), RPN2 (ER dolichyl-diphosphooligosaccharide transferase), TRAM1 (ER translocon), BCAP31 (ER membrane chaperone), TGOLN2 (trans-Golgi network), DHRS7 (ER reductase), and EHD2 (endosomal recycling) collectively define a coherent ER-to-lysosome protein processing and trafficking program. Significant upregulation in CD inflammation (delta=0.386) is consistent with increased lysosomal/autophagic activity during intestinal inflammation.
Genes
BCAP31, CTSD, DHRS7, EHD2, GRN, LAMP1, OS9, PSAP, RPN2, TGOLN2, TRAM1
Most correlated modules
- Metabolic Housekeeping · correlation 0.91
- Integrin Focal Adhesion · correlation 0.91
- Mitochondrial Translation · correlation 0.88
- Glycolytic Housekeeping · correlation 0.86
- Vascular Lumen Formation · correlation 0.84
- Mitochondrial OxPhos Complex · correlation 0.84
- Lymphatic EC Identity · correlation 0.84
- Fatty Acid Oxidation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.