Innate Immune Activation
Gene co-expression module in Lymphatic endothelial
| Category | Immune regulation |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 18 genes have a known function matching the annotation |
Why this annotation
This module is significantly upregulated in CD inflammation (delta=0.856, sig.). Key genes include CD46 (complement regulator), PROS1 (protein S, anticoagulant/immune modulator), EIF2AK2/PKR (innate immune dsRNA sensor), PRKDC and XRCC5 (DNA-PK complex for DNA repair and V(D)J recombination/innate sensing), TJP1 (tight junction integrity), CLTC (endocytosis). The combination of complement regulation, innate immune sensing, and DNA damage response in an inflammation-responsive module suggests an innate immune activation/complement regulation program in lymphatic endothelium during intestinal inflammation.
Genes
CD46, CLTC, CRIM1, EIF2AK2, ENSA, FEZ2, GSN, PDLIM3, PON2, PRKDC, PROS1, SERINC3, SLC44A2, SUN2, TJP1, TM9SF2, XRCC5, ZC3H13
Most correlated modules
- Lymphatic Specification · correlation 0.92
- Vascular Lumen Formation · correlation 0.91
- Endothelial Identity · correlation 0.90
- Septin Cytoskeleton · correlation 0.84
- Endothelial Identity · correlation 0.77
- Mitochondrial Translation · correlation 0.76
- Lymphangiogenesis ECM · correlation 0.76
- Anticoagulant Barrier · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.