Mitochondrial Translation
Gene co-expression module in Lymphatic endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 10 genes have a known function matching the annotation |
Why this annotation
MTIF3 (mitochondrial translation initiation factor 3) is the top hub, pointing to mitochondrial translation. SCP2 (sterol carrier protein 2) is involved in lipid/sterol transfer. CHMP3 is an ESCRT-III component for endosomal sorting. SERPINB6 is a cytoplasmic serine protease inhibitor. NUCB2 is a calcium-binding secretory protein. LEPROT modulates leptin receptor trafficking. CCDC25 is a NET/DNA sensor. RTF2 is involved in replication fork stability. The module is heterogeneous but the top hub and several members point to mitochondrial translation and general metabolic maintenance. Classified as mitochondrial translation given the dominant hub.
Genes
CCDC25, CHMP3, CPNE3, LEPROT, MTIF3, NUCB2, RTF2, SCP2, SERPINB6, TCEAL8
Most correlated modules
- Fatty Acid Oxidation · correlation 0.90
- Metabolic Housekeeping · correlation 0.89
- Integrin Focal Adhesion · correlation 0.88
- ER-Lysosomal Processing · correlation 0.88
- Oxidative Stress Protection · correlation 0.85
- Lymphatic EC Identity · correlation 0.85
- Mitochondrial OxPhos Complex · correlation 0.83
- Endothelial Identity · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.