RTF2 — Replication termination factor 2
RTF2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RTF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Mitochondrial OxPhos Mitochondrial & OxPhos | AP2M1, ATP5MF, ATP6V0B, AURKAIP1, BSG, CALM3, CLTB, CSNK2B +19 more | View in SCUBA |
| Gamma-delta T cells | ER-Lysosomal Trafficking Protein processing & ER | ARL6IP5, ATF6B, BORCS6, CD53, CLN3, DHRS7, MGAT1, MMP23B +12 more | |
| Innate lymphoid cells | RNA Splicing Processing RNA processing & translation | ATP5F1C, CHMP2A, CHMP4A, CYBA, DSTN, DYNC1I2, DYNLRB1, FKBP3 +16 more | View in SCUBA |
| Lymphatic endothelial | Mitochondrial Translation Mitochondrial & OxPhos | CCDC25, CHMP3, CPNE3, LEPROT, MTIF3, NUCB2, SCP2, SERPINB6 +1 more | View in SCUBA |
| Macrophages | Low-Coherence Mixed Technical artifact | AAMP, ALKBH7, CDC123, COMMD5, DNTTIP1, EIF3G, EIF4E2, FAM32A +8 more | View in SCUBA |
| Smooth muscle cells | NO-cGMP Signaling Contractility | AC005884.1, AC068888.1, AL355974.2, DEPP1, GUCY1A1, GUCY1B1, HIST1H4C, HOTAIRM1 +2 more | View in SCUBA |
About the gene
| Synonyms | C20orf43, CDAO5, HSPC164, RTFDC1 |
|---|---|
| Chromosome | 20: 56468585-56519449 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Plasma proteins, Predicted intracellular proteins |
Function
Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.