LEPROT — Leptin receptor overlapping transcript
LEPROT belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
LEPROT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Mitochondrial Translation Mitochondrial & OxPhos | CCDC25, CHMP3, CPNE3, MTIF3, NUCB2, RTF2, SCP2, SERPINB6 +1 more | View in SCUBA |
| Macrophages | Autophagy Lysosomal Regulation Lysosomal & pahgocytosis | ADIPOR1, ARL8A, ATOSB, BCL10, BROX, CCR1, CEBPB, CHMP2B +22 more | View in SCUBA |
| Smooth muscle cells | Sparse Mitoribosomal Housekeeping Housekeeping | CEP63, CIB1, CTNNA1, ERGIC3, FBXO17, MRPL32, MRPL41, MRPS7 +6 more | View in SCUBA |
About the gene
| Synonyms | FLJ90360, OB-RGRP, OBRGRP, VPS55 |
|---|---|
| Chromosome | 1: 65420587-65436007 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
Function
Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.