Lymphatic EC Identity
Gene co-expression module in Lymphatic endothelial
| Category | endothelial development |
|---|---|
| Genes | 11 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include CD151 and TSPAN4 (tetraspanins involved in membrane organization and cell adhesion), RAMP2 (a key lymphatic endothelial identity gene involved in adrenomedullin signaling), LMO2 (transcription factor critical for vascular/lymphatic development), GNG11 (G-protein signaling), and FDPS (isoprenoid/cholesterol biosynthesis). POLR2L (RNA polymerase subunit) and NAA38 (N-acetyltransferase) suggest housekeeping functions. MGST3 adds glutathione metabolism. The combination of lymphatic identity markers (RAMP2, LMO2) with membrane organization (CD151, TSPAN4) and basic metabolic genes reflects a core lymphatic endothelial identity program. All genes show uniform expression and core membership, consistent with a constitutively active housekeeping/identity module.
Genes
ATP6AP2, BEX3, CD151, FDPS, GNG11, LMO2, MGST3, NAA38, POLR2L, RAMP2, TSPAN4
Most correlated modules
- Caveolae Cytoskeletal · correlation 0.96
- Fatty Acid Oxidation · correlation 0.95
- Mitochondrial OxPhos Complex · correlation 0.94
- Oxidative Stress Protection · correlation 0.94
- Metabolic Housekeeping · correlation 0.93
- Oxidative Phosphorylation · correlation 0.91
- Housekeeping Mixed · correlation 0.89
- Mitochondrial OxPhos Complex · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.