Fatty Acid Oxidation
Gene co-expression module in Lymphatic endothelial
| Category | Lipid metabolism |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
ETFB (electron transfer flavoprotein beta subunit) and ECH1/ECHS1 (enoyl-CoA hydratases) are core fatty acid beta-oxidation enzymes. NDUFB10 is a Complex I subunit linking to OxPhos. PRDX2 is a peroxiredoxin involved in mitochondrial ROS detoxification. PEBP1 (phosphatidylethanolamine-binding protein) has roles in lipid metabolism and signaling. FCGRT (neonatal Fc receptor) is somewhat divergent but can be expressed in endothelial/lymphatic cells. TMEM14C is involved in heme biosynthesis in mitochondria. ATRAID is linked to mitochondrial function and bisphosphonate response. The dominant signal is mitochondrial fatty acid oxidation, supported by the OxPhos neighborhood context.
Genes
ATRAID, ECH1, ECHS1, ETFB, FCGRT, NDUFB10, PEBP1, PRDX2, TMEM14C
Most correlated modules
- Mitochondrial OxPhos Complex · correlation 0.96
- Lymphatic EC Identity · correlation 0.95
- Metabolic Housekeeping · correlation 0.94
- Housekeeping Mixed · correlation 0.94
- Oxidative Phosphorylation · correlation 0.93
- Caveolae Cytoskeletal · correlation 0.93
- Mitochondrial Translation · correlation 0.90
- Oxidative Stress Protection · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.