Metabolic Housekeeping
Gene co-expression module in Lymphatic endothelial
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes include DUT (nucleotide metabolism), ISCU (iron-sulfur cluster assembly), DMAC1 (mitochondrial complex I assembly factor), CYB5R3 (mitochondrial electron transfer), PPCS (CoA biosynthesis), OCIAD1 (mitochondrial), and CAPNS1 (calpain regulatory subunit). The module reflects broad metabolic housekeeping functions spanning mitochondrial maintenance and nucleotide/cofactor biosynthesis. Uniform expression across all subsets with moderate detection supports a constitutive housekeeping program.
Genes
CAPNS1, CYB5R3, DMAC1, DUT, EID1, ESD, GNAI2, ISCU, OCIAD1, PNKD, PPCS, TMEM109, TMEM179B, ZFYVE21
Most correlated modules
- Mitochondrial OxPhos Complex · correlation 0.95
- Fatty Acid Oxidation · correlation 0.94
- Lymphatic EC Identity · correlation 0.93
- ER-Lysosomal Processing · correlation 0.91
- Mitochondrial OxPhos Complex · correlation 0.91
- Caveolae Cytoskeletal · correlation 0.91
- Oxidative Phosphorylation · correlation 0.91
- Housekeeping Mixed · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.