Mitochondrial OxPhos Complex
Gene co-expression module in Lymphatic endothelial
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 14 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
The module is dominated by NADH dehydrogenase (Complex I) subunits: NDUFA11, NDUFA4, NDUFAF3, NDUFB7, NDUFC2, plus COX5B (Complex IV) and UQCRQ (Complex III). FIS1 is a mitochondrial fission protein, MRPL43 is a mitochondrial ribosomal protein. ARL2 regulates mitochondrial morphology. BLOC1S1 and DCTN3 are vesicle/cytoskeletal components but co-expressed here. The module is uniformly expressed, tightly coherent, and clearly represents mitochondrial oxidative phosphorylation machinery. Neighbor modules (M57, M23, M86) also contain NDUF subunits and COX subunits, confirming a neighborhood of OxPhos-related programs.
Genes
ARL2, BLOC1S1, CHMP2A, CHURC1, COX5B, DCTN3, FIS1, MRPL43, NDUFA11, NDUFA4, NDUFAF3, NDUFB7, NDUFC2, UQCRQ
Most correlated modules
- Fatty Acid Oxidation · correlation 0.96
- Housekeeping Mixed · correlation 0.96
- Metabolic Housekeeping · correlation 0.95
- Mitochondrial OxPhos Complex · correlation 0.95
- Oxidative Phosphorylation · correlation 0.95
- Lymphatic EC Identity · correlation 0.94
- Oxidative Stress Response · correlation 0.92
- Caveolae Cytoskeletal · correlation 0.91
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.