IL33 Alarmin Response
Gene co-expression module in Lymphatic endothelial
| Category | Inflammation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 13 genes have a known function matching the annotation |
Why this annotation
IL33 is the dominant hub gene — a nuclear alarmin cytokine released by lymphatic and vascular endothelial cells during inflammation, hypoxia, or mechanical stress to activate ILC2s and mast cells. EPAS1 (HIF-2α) links this to hypoxic stress. TGM2, IGFBP5, PRELP, and SFRP1 indicate ECM remodeling and Wnt pathway modulation. PLAT (tPA) is a known lymphatic endothelial product. CLIC4 and PLSCR1 are stress/TGF-β-responsive genes. LIFR (LIF receptor) and SRPX add cytokine signaling and angiogenic context. Together these genes define an IL33-centered inflammatory alarmin and ECM stress response program in lymphatic endothelium, consistent with the elevated (though non-significant) delta_inflammation_CD score.
Genes
CLIC4, EPAS1, HRCT1, IGFBP5, IL33, LIFR, PLAT, PLSCR1, PRELP, SFRP1, SRPX, TGM2, TMT1A
Most correlated modules
- Endothelial Receptor Signaling · correlation 0.74
- Vascular Lumen Formation · correlation 0.73
- Innate Immune Activation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.