PLAT — Plasminogen activator, tissue type
PLAT belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PLAT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | CA4, CABP1, CD36, FABP5, FMNL2, IGFBP6, ISLR, LNX1 +6 more | View in SCUBA |
| Fibroblasts | WNT-modulating Fibroblast Developmental | CIB2, COL4A5, DMKN, F3, FIP1L1, FRZB, GPSM3, HSD17B2 +9 more | View in SCUBA |
| Glial cells | Oxidative Stress Response Stress | CAP1, CD59, CXXC5, EEF2, ENO1, HNRNPF, KLF9, NDUFA11 +3 more | View in SCUBA |
| Lymphatic endothelial | IL33 Alarmin Response Inflammation | CLIC4, EPAS1, HRCT1, IGFBP5, IL33, LIFR, PLSCR1, PRELP +4 more | View in SCUBA |
About the gene
| Chromosome | 8: 42174718-42207709 |
|---|---|
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
| Biological process | Plasminogen activation |
Function
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.