CLIC4 — Chloride intracellular channel 4
CLIC4 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CLIC4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Angiogenic Identity Endothelial cell development | ACTN4, ADGRL4, APBB2, CAVIN1, CD93, CLEC14A, ESAM, MYH9 +5 more | View in SCUBA |
| Fibroblasts | Focal Adhesion ECM Migration & adhesion | ACTN1, COL4A1, COL4A2, MPRIP, MRPL33, MYL6, NDUFA4, PARVA +6 more | View in SCUBA |
| Glial cells | Lysosomal Sphingolipid Metabolism Housekeeping | ASAH1, BEX4, EID1, LAMP1, PSAP, SERPINB6, SGCE, SSPN | View in SCUBA |
| Lymphatic endothelial | IL33 Alarmin Response Inflammation | EPAS1, HRCT1, IGFBP5, IL33, LIFR, PLAT, PLSCR1, PRELP +4 more | View in SCUBA |
| Macrophages | Alternative Activation Lipid Lipid metabolism | ACSL1, ADCY3, AGFG1, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13 +24 more | View in SCUBA |
| Pericytes | Golgi Vesicular Trafficking Vesicular traficking | APP, CTNNA1, EMP2, GNAS, PAK2, PTTG1IP, SERINC3, TGOLN2 +1 more | View in SCUBA |
| Smooth muscle cells | mRNA Splicing Factors RNA processing & translation | ATF4, BEX3, COX20, HNRNPA0, NAP1L1, NDUFA6, NME4, PCBP1 +7 more | View in SCUBA |
About the gene
| Synonyms | CLIC4L, DKFZP566G223, H1, huH1, P64H1 |
|---|---|
| Chromosome | 1: 24745382-24844321 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transporters |
| Molecular function | Chloride channel, Ion channel, Oxidoreductase, Voltage-gated channel |
| Biological process | Ion transport, Transport |
Function
In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.