SFRP1 — Secreted frizzled related protein 1

SFRP1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SFRP1's module in each cell type

Cell type	Module	Shares the module with
Fibroblasts	Subepithelial Fibroblast Identity Developmental	ANGPTL1, APBB1IP, ARHGAP15, CNTN1, CP, ECM2, EFEMP1, FAM107A +12 more	View in SCUBA
Glial cells	Glial Adhesion Identity migration & adhesion	ADAM23, CADM4, CALU, DAG1, HMCN1, HMGN1, ITGA2, PTPRZ1 +2 more	View in SCUBA
Lymphatic endothelial	IL33 Alarmin Response Inflammation	CLIC4, EPAS1, HRCT1, IGFBP5, IL33, LIFR, PLAT, PLSCR1 +4 more	View in SCUBA
Smooth muscle cells	Stromal Chemokine Secretion Inflammation	C7, CCL19, CCL2, CCL21, CH25H, CXCL12, CXCL2, LINC00924 +9 more	View in SCUBA

About the gene

Synonyms	FRP, FRP-1, SARP2
Chromosome	8: 41261962-41309473
Predicted location	Intracellular, Secreted
Essential gene	No
Protein class	Predicted intracellular proteins, Predicted secreted proteins, Transporters
Molecular function	Developmental protein
Biological process	Differentiation, Wnt signaling pathway

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF- dependent transcription

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.