SERINC5 — Serine incorporator 5
SERINC5 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SERINC5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T-cell quiescence regulation Immune regulation | CDC42SE2, CDKN1B, FOXP1, ICAM2, KRAS, MRPS6, MSL3, SLC5A3 +4 more | View in SCUBA |
| Lymphatic endothelial | Endosomal Vesicle Trafficking Housekeeping | ADAM10, APC, APP, ATP9A, GLG1, MTR, NCOA3, PCNX4 +5 more | View in SCUBA |
| Macrophages | Innate Immune Dampening Innate immunity | DCAF6, ELL2, FGD4, FKBP5, IRAK3, MAP2K4, MOB3B, PACSIN2 +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | Naive T cell T cell maturation | AK5, ARID5B, BACH2, CCR7, CSGALNACT1, FHIT, FOXP1, LEF1 +6 more |
About the gene
| Synonyms | C5orf12, TPO1 |
|---|---|
| Chromosome | 5: 80111651-80256048 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism |
Function
Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non- specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity. Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.