Chromatin Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
TFDP2 (DP-2, E2F dimerization partner) and CHD6 (chromatin helicase) point to cell cycle entry and chromatin regulation. P2RY8 is a purinergic receptor linked to lymphocyte quiescence/retention. NLRP1 is an inflammasome sensor. KLF3 is a transcriptional repressor involved in lymphocyte homeostasis. SF3B6 and SNU13 are spliceosome components. ATF7IP2 is involved in chromatin/epigenetic regulation. The module is moderate coherence, suggesting a mixed regulatory/chromatin state, but TFDP2/CHD6 and splicing components anchor it to DNA/chromatin regulation.
Genes
ATF7IP2, CHD6, KLF3, LYST, NLRP1, OSBPL8, P2RY8, SF3B6, SNU13, TFDP2
Most correlated modules
- Cytoskeletal Migration · correlation 0.72
- Transcriptional Repression · correlation 0.68
- PI3K-Calcineurin Signaling · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.