P2RY8 — P2Y receptor family member 8
P2RY8 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
P2RY8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Germinal center B-cell B cell maturation | BACH2, BCL6, BPTF, GGA2, MAP4K4, MBD4, MCTP2, MSI2 +7 more | View in SCUBA |
| CD4⁺ T cells | GIMAP survival Immune regulation | ABLIM1, AKT3, ANKRD13D, ARL4C, C16orf54, CA5B, COPA, CRBN +16 more | View in SCUBA |
| Endothelial | Venous EC Identity Endothelial cell development | CA4, CABP1, CD36, FABP5, FMNL2, IGFBP6, ISLR, LNX1 +6 more | View in SCUBA |
| Gamma-delta T cells | Naive T cell quiescence T cell maturation | ADAP1, ARL4C, BCL9L, BMAL1, CALM1, CAMK1D, CD44, CD5 +10 more | |
| Mucosal-associated invariant T cell | Chromatin Regulation DNA/chromatin regulation | ATF7IP2, CHD6, KLF3, LYST, NLRP1, OSBPL8, SF3B6, SNU13 +1 more | |
| Natural Killer cells | Lymphocyte Trafficking Homing & TEM | BCL6, CTSD, LAPTM5, LITAF, ORAI1, PTPRJ, RNF166, S1PR1 +3 more | View in SCUBA |
About the gene
| Synonyms | P2Y8 |
|---|---|
| Chromosome | X: 1462581-1537185 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
G protein-coupled receptor for S-geranylgeranyl-glutathione (GGG), an endogenous metabolite present in lymphoid tissues. Couples the binding of GGG to the activation of GNA13 and downstream repression of AKT activation in lymphocytes defining their positioning and growth within lymphoid organs. In lymphoid follicles, confines B cells and follicular helper T cells in germinal centers (GCs) in response to GGG local gradients established by GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) with lower concentrations of GGG found in the follicular dendritic cell network region around which germinal centers are formed. In the bone marrow, also in response to GGG gradients established by GGT5 and ABCC1, it restricts chemotactic transmigration of B cells, T cells and NK cells from blood vessels to the bone marrow parenchyma. Contributes to GNA13-dependent pathway that suppresses GC B cell growth.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.