TFDP2 — Transcription factor Dp-2
TFDP2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TFDP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | PPARA/FXR fatty acid oxidation Lipid metabolism | ALDH18A1, ANO10, CPT1A, DGKD, FAT1, FMO5, NDRG1, NR1H4 +4 more | View in SCUBA |
| Gamma-delta T cells | Terminal T Differentiation T cell maturation | AXIN1, B3GAT1, C1orf174, CEBPA, ENC1, F2R, GLUL, GTF3C1 +10 more | |
| Mucosal-associated invariant T cell | Chromatin Regulation DNA/chromatin regulation | ATF7IP2, CHD6, KLF3, LYST, NLRP1, OSBPL8, P2RY8, SF3B6 +1 more | |
| Natural Killer cells | NK Homing & Residency Homing & TEM | C11orf21, CD47, CTSW, FXYD5, PRMT2, RIPOR2, S1PR4, SAMHD1 +2 more | View in SCUBA |
About the gene
| Synonyms | Dp-2 |
|---|---|
| Chromosome | 3: 141944428-142149544 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding |
| Biological process | Cell cycle, Transcription, Transcription regulation |
Function
Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell- cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.