SNU13 — Small nuclear ribonucleoprotein 13
SNU13 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SNU13's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | RNA Splicing Complex RNA processing & translation | ATP6V0B, ATP6V1F, EIF3I, MRPS6, NDUFS7, PARK7, PRDX6, PSMD4 +3 more | View in SCUBA |
| Fibroblasts | General Housekeeping Housekeeping | ATP6V0E1, C19orf53, CLTA, EDF1, ERH, NEDD8, PARK7, SEC11A +4 more | View in SCUBA |
| Gamma-delta T cells | Chromatin-Splicing Regulation DNA/chromatin regulation | ANKRD11, BOD1L1, CAMLG, CEBPB, EAPP, FMR1, KMT2B, MED10 +13 more | |
| Goblet cells | Mitochondrial Biogenesis Mitochondrial & OxPhos | ARPC5L, CALM1, EIF5A, LSM7, MRPL17, MRPL20, MRPL41, PFN1 +4 more | View in SCUBA |
| Innate lymphoid cells | RNA-binding & Splicing RNA processing & translation | CALM1, DYNLL1, FUS, HNRNPA2B1, HNRNPAB, NCL, NUDC, PPIG +4 more | View in SCUBA |
| Macrophages | Mitochondrial Biogenesis Mitochondrial & OxPhos | AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1 +38 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Regulation DNA/chromatin regulation | ATF7IP2, CHD6, KLF3, LYST, NLRP1, OSBPL8, P2RY8, SF3B6 +1 more |
About the gene
| Synonyms | 15.5K, FA-1, NHP2L1, SNRNP15-5, SPAG12, SSFA1 |
|---|---|
| Chromosome | 22: 41673933-41690504 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Ribosomal proteins |
| Molecular function | Ribonucleoprotein, RNA-binding |
| Biological process | mRNA processing, mRNA splicing |
Function
Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre- rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre- ribosomal RNA by the RNA exosome. Involved in pre- mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.