Transcriptional Repression

Gene co-expression module in Mucosal-associated invariant T cell

Why this annotation

This module contains several notable immune regulatory genes. CMIP (c-Maf inducing protein) is a signaling adaptor that activates NF-AT and is involved in T cell differentiation/immunosuppression. TNFRSF1B (TNF receptor 2) mediates TNF signaling in T cells and regulatory T cell function. NR3C1 (glucocorticoid receptor) is a major transcriptional regulator of T cell function and anti-inflammatory responses. MXI1 is a MYC antagonist/transcriptional repressor. RCOR1 (CoREST) is a transcriptional corepressor. SP3 is a general transcription factor. RNF168 is an E3 ubiquitin ligase involved in DNA damage response (H2AK13/15 ubiquitination). RNF115 is an E3 ligase with immune regulatory roles. PELI2 is a Pellino E3 ligase in innate immune/NF-κB signaling. RB1CC1 (FIP200) is an autophagy initiator. ANKRD11 is a transcriptional repressor. TENT4B is a non-canonical poly(A) polymerase. TNRC6A is part of the RISC complex. ZFAND6 and PROSER1 and RFTN1 are less characterized. The convergent theme involves transcriptional repression and immune regulation/suppression (CMIP, NR3C1, RCOR1, MXI1, TNFRSF1B, PELI2), suggesting a module related to T cell immune regulation and signal dampening.

Genes

ANKRD11, CMIP, MXI1, NR3C1, PELI2, PROSER1, RB1CC1, RCOR1, RFTN1, RNF115, RNF168, SP3, TENT4B, TNFRSF1B, TNRC6A, ZFAND6

Most correlated modules

• Epigenetic Chromatin Regulation · correlation 0.79
• Nuclear-Cytoplasmic Transport · correlation 0.72
• Chromatin Regulation · correlation 0.68
• SWI/SNF Chromatin Remodeling · correlation 0.65
• Cytoskeletal Migration · correlation 0.59
• Immune Synapse Signaling · correlation 0.59

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.