Vesicular Trafficking
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 14 genes have a known function matching the annotation |
Why this annotation
Top hub genes ATP6V1G1 (vacuolar H+-ATPase subunit, lysosomal acidification), VAMP2 (synaptobrevin/SNARE protein, vesicle fusion), and CALM1 (calmodulin, calcium signaling) point to vesicular trafficking and calcium-dependent membrane dynamics. Supporting genes include PSMD7 (26S proteasome), RNF126 (E3 ubiquitin ligase for misfolded membrane proteins), GET4 (guided entry of tail-anchored proteins), and MED10 (Mediator transcription coactivator). ATP5PO and SLC25A3 reflect mitochondrial contributions shared with neighbor M29. KLF2 is a notable T cell quiescence/tissue-residence transcription factor but is a peripheral member. The module reflects a mixed cellular housekeeping program anchored in vesicular/lysosomal membrane biology.
Genes
ATP5PO, ATP6V1G1, CALM1, EEF1G, GET4, KLF2, MED10, MZT2B, PSMD7, RNF126, SLC25A3, SYF2, TLE5, VAMP2
Most correlated modules
- TGF-beta Response · correlation 0.85
- Translation Elongation · correlation 0.82
- T cell Surface Signaling · correlation 0.79
- Leukocyte Housekeeping · correlation 0.75
- Mitochondrial OxPhos · correlation 0.66
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.