VAMP2 — Vesicle associated membrane protein 2
VAMP2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
VAMP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Modification DNA/chromatin regulation | AKAP13, CREBRF, EPC1, GCC2, GPBP1, JMJD1C, KMT2E, OFD1 +6 more | View in SCUBA |
| Gamma-delta T cells | TCR Vesicular Trafficking TCR Signaling | ARL2BP, ARL8A, ARRDC1, C18orf32, CCDC92, CD3D, CD3G, CD99 +14 more | |
| Glial cells | Glial Vesicle Trafficking Housekeeping | BEX3, CCNI, FKBP1A, HMGN2, ITM2C, PGRMC1, PLD3, TCEAL7 +1 more | View in SCUBA |
| Macrophages | Macrophage Endocytic Signaling Lysosomal & pahgocytosis | APLP2, ARHGAP30, ARHGEF2, ATF6B, BAG6, CLSTN1, CMTR2, CTBS +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Vesicular Trafficking Housekeeping | ATP5PO, ATP6V1G1, CALM1, EEF1G, GET4, KLF2, MED10, MZT2B +5 more | |
| Smooth muscle cells | Basal Maintenance Genes Housekeeping | ANAPC16, C1QTNF2, C7orf50, CCNI, COX14, COX8A, HNRNPA1, MRPL33 +3 more | View in SCUBA |
About the gene
| Synonyms | SYB2, VAMP-2 |
|---|---|
| Chromosome | 17: 8159149-8163546 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Predicted membrane proteins, Transporters |
Function
Involved in the targeting and/or fusion of transport vesicles to their target membrane (By similarity). Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles (By similarity). Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.