T cell Surface Signaling
Gene co-expression module in Mucosal-associated invariant T cell
| Category | TCR Signaling |
|---|---|
| Genes | 8 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
LIME1 (Lck/Fyn-interacting membrane protein involved in T cell receptor signaling), ICAM3 (intercellular adhesion molecule expressed on T cells, co-stimulatory), and CD37 (tetraspanin critical for T/B cell function and signaling complex organization) are the top hubs. SIGIRR (single immunoglobulin IL-1R, negative regulator of TLR/IL-1 signaling), MFNG (Notch pathway modifier affecting T cell development), PLSCR3 (phospholipid scramblase), MZT2A (microtubule nucleation), and NAA10 (N-terminal acetyltransferase) round out the module. The dominant theme is T cell surface signaling and immune regulation, consistent with MAIT cell baseline identity.
Genes
CD37, ICAM3, LIME1, MFNG, MZT2A, NAA10, PLSCR3, SIGIRR
Most correlated modules
- Leukocyte Housekeeping · correlation 0.89
- Cytotoxic Lymphocyte Program · correlation 0.88
- Mitochondrial Housekeeping · correlation 0.87
- Cytoskeletal Remodeling Migration · correlation 0.87
- T cell Homeostasis · correlation 0.84
- Mitochondrial OxPhos · correlation 0.83
- TCR Signaling Identity · correlation 0.82
- Cytotoxic Effector · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.