Leukocyte Housekeeping
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 14 genes have a known function matching the annotation |
Why this annotation
GMFG (glia maturation factor gamma, regulates actin dynamics in leukocytes), HCST/DAP10 (adaptor for NKG2D activating receptor expressed on MAIT/NK/T cells), APRT (adenine phosphoribosyltransferase, purine salvage), S100A6 (calcium-binding, expressed in T cells), ATP5MC2 (ATP synthase, Complex V), EIF3G (translation initiation), MICOS13 (mitochondrial contact site), NDUFB9 (Complex I), GABARAPL2 (autophagy/LC3 family), PSMB3 (proteasome beta subunit), ERP29 (ER lumenal protein), AP2S1 (clathrin adaptor), CCDC85B, SELENOW. High mean expression and detection rate. HCST/DAP10 and GMFG are leukocyte-specific; the rest are broadly expressed metabolic/proteostasis genes. The module reflects constitutive MAIT housekeeping with a leukocyte activating receptor adaptor signature.
Genes
AP2S1, APRT, ATP5MC2, CCDC85B, EIF3G, ERP29, GABARAPL2, GMFG, HCST, MICOS13, NDUFB9, PSMB3, S100A6, SELENOW
Most correlated modules
- Mitochondrial Housekeeping · correlation 0.94
- T cell Surface Signaling · correlation 0.89
- Translation Elongation · correlation 0.88
- Cytotoxic Lymphocyte Program · correlation 0.87
- Cytotoxic Effector · correlation 0.86
- Mitochondrial OxPhos · correlation 0.85
- T cell Homeostasis · correlation 0.83
- T cell Identity · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.