Mitochondrial OxPhos
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 3 of 12 genes have a known function matching the annotation |
Why this annotation
Top hub genes NDUFB1 and NDUFA3 are NADH dehydrogenase (Complex I) subunits, and ATP5MF is an ATP synthase subunit, anchoring this module firmly in oxidative phosphorylation. Remaining genes (SEM1, H2AZ1, H4C3, SKP1, INO80E, THOC7) represent general housekeeping machinery. Uniform expression across all subsets and strong coherence support a constitutive mitochondrial/OxPhos housekeeping program. Neighbor context: co-expressed with other housekeeping modules (M100, M31), consistent with a shared basal metabolic program.
Genes
ATP5MF, H2AZ1, H4C3, INO80E, LYPLA2, NDUFA3, NDUFB1, SEM1, SGSM3, SKP1, TBCA, THOC7
Most correlated modules
- Mitochondrial Housekeeping · correlation 0.91
- T cell Identity · correlation 0.85
- Leukocyte Housekeeping · correlation 0.85
- TCR Signaling Identity · correlation 0.84
- T cell Homeostasis · correlation 0.83
- T cell Surface Signaling · correlation 0.83
- ATP Synthase Complex · correlation 0.78
- Mitochondrial Biogenesis · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.