TGF-beta Response
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Immune regulation |
|---|---|
| Genes | 30 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 30 genes have a known function matching the annotation |
Why this annotation
TGFB1 is the top hub, a central immunomodulatory cytokine driving regulatory and tissue-resident programs in T cells including MAITs. Supporting genes include mitochondrial components (UQCRB complex III, TOMM20 import, SLC25A5 ANT2, DNLZ), cytoskeletal regulator FMNL1 (formin, involved in T cell migration and immunological synapse), CD48 (adhesion/NK-T cell signaling), SUN2 (LINC complex, nuclear-cytoskeletal coupling). RNA binding genes (PABPC4, ILF2, RBM3) add post-transcriptional regulation. The module reflects a TGFB1-centered immunoregulatory state with associated metabolic and cytoskeletal remodeling consistent with tissue-resident or regulatory MAIT activation.
Genes
ABCA1, ARL4C, ARRDC2, CD48, DDX47, DNLZ, ERGIC1, FMNL1, HYPK, ILF2, KBTBD2, KLRB1, LTK, NOP53, PABPC4, PCIF1, PLEKHA3, RBM3, RBM34, RNF114, RNF166, ROR2, RSL24D1, SLC25A5, SUN2, TGFB1, TOMM20, UQCRB, UQCRFS1, XBP1
Most correlated modules
- Vesicular Trafficking · correlation 0.85
- mRNA 3' Processing · correlation 0.83
- mRNA Decay Program · correlation 0.76
- Nuclear Receptor Chromatin · correlation 0.76
- Autophagy & Trafficking · correlation 0.75
- Housekeeping Translation · correlation 0.74
- Retinoic Acid Response · correlation 0.73
- RNA Splicing m6A · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.