Translation Elongation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 17 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 11 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes FAU (ubiquitin-ribosomal S30 fusion), EEF1B2 and EEF1D (translation elongation factors), RACK1 (ribosome receptor for signaling), UBA52 (ubiquitin-ribosomal L40 fusion), NACA (nascent polypeptide-associated complex), EIF3K (translation initiation factor subunit), and BTF3 (nascent polypeptide-associated complex beta) define a strong translational machinery module. PFDN5 (prefoldin, cotranslational chaperone), SNRPD2 (spliceosome, supports nascent mRNA), NPM1 (ribosome biogenesis) further support this. Core coherence with 91% pct positive indicates constitutive high expression — classic ribosome/translation housekeeping. COX4I1, SLC25A6, GPX4, FTL, BAX are peripheral members. Neighbor context: all three modules represent housekeeping programs; M100 is the most tightly translation-focused.
Genes
BAX, BTF3, COX4I1, EEF1B2, EEF1D, EIF3K, FAU, FTL, GPX4, NACA, NPM1, PFDN5, RACK1, S100A4, SLC25A6, SNRPD2, UBA52
Most correlated modules
- Leukocyte Housekeeping · correlation 0.88
- Vesicular Trafficking · correlation 0.82
- Mitochondrial Housekeeping · correlation 0.80
- T cell Surface Signaling · correlation 0.79
- Cytotoxic Lymphocyte Program · correlation 0.74
- Mitochondrial OxPhos · correlation 0.73
- Cyclophilin-Mediated Folding · correlation 0.72
- ATP Synthase Complex · correlation 0.70
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.