Circadian Innate Signaling
Gene co-expression module in Natural Killer cells
| Category | Inflammation |
|---|---|
| Genes | 10 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub gene SLC15A4 is an endosomal peptide/histidine transporter essential for TLR7/TLR9 signaling and innate immune activation in lymphocytes. CRY1 and NOCT are core circadian clock components. ITPRIP modulates IP3 receptor calcium signaling. UPP1 is involved in nucleotide salvage. PTPRE is a tyrosine phosphatase regulating immune receptor signaling. The module is significantly upregulated in IBD inflammation. The co-occurrence of SLC15A4 (innate immune sensing) with circadian genes (CRY1, NOCT) reflects the known circadian regulation of innate immune responses. Neighbor modules M82 (PER1) and M52 (NR1D2) also contain circadian genes, supporting a circadian-inflammatory program across this batch.
Genes
ARRDC2, CRY1, ITPRIP, MGAT4A, NOCT, PTPRE, SLC15A4, TRAPPC10, UAP1, UPP1
Most correlated modules
- NK Cell Exhaustion · correlation 0.77
- KIR+ NK Maturation · correlation 0.67
- NK Cell Maturation · correlation 0.66
- TGF-beta Response · correlation 0.64
- Innate Sensing NK Regulation · correlation 0.59
- Granulysin Cytotoxic Effector · correlation 0.56
- NF-κB Activation · correlation 0.55
- Lymphocyte Trafficking · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.