UPP1 — Uridine phosphorylase 1
UPP1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
UPP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Wnt Angiogenic Remodeling ECM remodeling | ADAMTS4, ADGRL2, BAZ1A, FKBP11, IL4R, LDLRAD3, LEF1, MTHFD2 +5 more | View in SCUBA |
| Macrophages | Osmotic Stress Response Stress | ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more | View in SCUBA |
| Monocytes | Inflammatory Autophagy Lysosomal & pahgocytosis | ATG2A, MAP1LC3B, RABGEF1, RELT, SESN2, TOM1, UBALD2 | View in SCUBA |
| Natural Killer cells | Circadian Innate Signaling Inflammation | ARRDC2, CRY1, ITPRIP, MGAT4A, NOCT, PTPRE, SLC15A4, TRAPPC10 +1 more | View in SCUBA |
| Neutrophils | Mature Neutrophil Activation Innate immunity | AIF1, ALOX5AP, C4orf3, CD14, MCEMP1, PRELID1, SLC2A3, TIMP1 +1 more | |
| Pericytes | NF-κB Inflammatory Response Inflammatory | ABL2, ADAMTS9, ARL4A, BCL3, BHLHE40, FOSL2, ICAM1, KLF10 +3 more | View in SCUBA |
About the gene
| Synonyms | UDRPASE, UP, UPASE, UPP |
|---|---|
| Chromosome | 7: 48088628-48108736 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Glycosyltransferase, Transferase |
Function
Catalyzes the reversible phosphorylytic cleavage of uridine to uracil and ribose-1-phosphate which can then be utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows broad substrate specificity and can also accept deoxyuridine and other analogous compounds (Probable)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.