Innate Sensing NK Regulation
Gene co-expression module in Natural Killer cells
| Category | Immune regulation |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 10 genes have a known function matching the annotation |
Why this annotation
PYHIN1 (pyrin and HIN domain family member 1) is an innate immune sensor involved in inflammasome activation and cytosolic DNA sensing, expressed in NK and myeloid cells. FCRL6 (Fc receptor-like 6) is an inhibitory receptor preferentially expressed on NK cells and cytotoxic T cells that modulates NK cell function. ADRB2 (beta-2 adrenergic receptor) modulates NK cell activity via sympathetic nervous system signaling. PLEK (pleckstrin) is a downstream effector of NK cell activation. PRR5L is part of mTORC2 signaling relevant to NK cell metabolism and activation. LFNG modifies Notch receptors affecting NK cell differentiation. Module is significantly upregulated in UC/CD inflammation and reduced in remission.
Genes
ADRB2, DTHD1, FCRL6, LFNG, LIMD2, PLEK, PRR5L, PYHIN1, UBE2F, ZNF276
Most correlated modules
- Cytotoxic NK Maturation · correlation 0.80
- NK Cell Maturation · correlation 0.79
- NK Homing Adhesion · correlation 0.77
- NK Homing & Residency · correlation 0.73
- NK Activation Signaling · correlation 0.71
- Granulysin Cytotoxic Effector · correlation 0.71
- Cytoskeletal Remodeling · correlation 0.70
- NK Degranulation Activation · correlation 0.69
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.