TGF-beta Response
Gene co-expression module in Natural Killer cells
| Category | Immune regulation |
|---|---|
| Genes | 11 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
TGFB1 is the most functionally prominent gene — a master immunosuppressive cytokine that drives NK cell dysfunction and regulatory programs in the intestinal microenvironment. ZFPM1 (FOG1) is a transcriptional co-repressor of GATA factors involved in hematopoietic differentiation. RBM38 is an RNA-binding protein and p53 target regulating mRNA stability. GNA13 activates Rho GTPase signaling downstream of GPCRs. AUTS2 is a transcriptional regulator. CDK17 is a cyclin-dependent kinase. TGFB1 upregulation in CD inflammation with treatment reversal is consistent with TGF-β-mediated immune suppression in IBD. The module likely reflects TGF-β-driven regulatory reprogramming of NK cells in inflamed intestine.
Genes
ANKRD9, AUTS2, CDK17, GNA13, MTFP1, N4BP3, RAB5IF, RBM38, TAMALIN, TGFB1, ZFPM1
Most correlated modules
- Circadian NF-κB Crosstalk · correlation 0.68
- Circadian Innate Signaling · correlation 0.64
- Housekeeping Mixed · correlation 0.63
- KIR+ NK Maturation · correlation 0.62
- NK Cell Exhaustion · correlation 0.61
- Lymphocyte Trafficking · correlation 0.55
- NK Cell Identity · correlation 0.38
- NK Cytotoxic Signaling · correlation 0.37
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.