NOCT — Nocturnin
NOCT belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOCT's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | TGF-beta Response Immune regulation | ADGRE5, CD83, CHMP1B, CHST7, DDIT3, DNAAF2, EHD4, FAM43A +15 more | |
| Monocytes | Non-canonical NF-κB Innate immunity | AMPD2, BCL3, BEST1, DENND5A, FAM20A, NFKB2, RELB, TICAM1 | View in SCUBA |
| Mucosal-associated invariant T cell | Stress-Induced Growth Arrest Stress | CDKN1A, GNA15, KDM6B, KLF10, MMP9, MYADM, NR4A3, PLK3 +8 more | |
| Natural Killer cells | Circadian Innate Signaling Inflammation | ARRDC2, CRY1, ITPRIP, MGAT4A, PTPRE, SLC15A4, TRAPPC10, UAP1 +1 more | View in SCUBA |
About the gene
| Synonyms | Ccr4c, CCR4L, CCRN4L, NOC |
|---|---|
| Chromosome | 4: 139015781-139045939 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Repressor, RNA-binding |
| Biological process | Biological rhythms |
Function
Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH. Shows a small preference for NADPH over NADP(+). Represses translation and promotes degradation of target mRNA molecules. Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post- transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.