DNA Replication
Gene co-expression module in Natural Killer cells
| Category | Cell cycle |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes FEN1 (flap endonuclease, DNA replication/repair), MCM7 (minichromosome maintenance helicase, replication licensing), DHFR (dihydrofolate reductase, nucleotide synthesis), UHRF1 (DNA methylation maintenance, S-phase), TK1 (thymidine kinase, nucleotide salvage, S-phase marker), TMEM106C (transmembrane protein), PCNA (proliferating cell nuclear antigen, master S-phase clamp), ATAD2 (chromatin remodeling, replication), LIG1 (DNA ligase I, Okazaki fragment ligation). This is a highly coherent DNA replication/S-phase module, closely related to M73. Together these two modules represent the S-phase proliferation program in NK cells, upregulated in CD inflammation.
Genes
ATAD2, DHFR, FEN1, LIG1, MCM7, PCNA, TK1, TMEM106C, UHRF1
Most correlated modules
- S-phase Replication · correlation 0.97
- G2/M Transition · correlation 0.88
- Chromatin Remodeling · correlation 0.82
- Replication Histones · correlation 0.72
- Glycolytic Metabolism · correlation 0.71
- Mitotic Spindle · correlation 0.65
- Energy Metabolism · correlation 0.59
- Histone Variant Remodeling · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.