Mitotic Spindle
Gene co-expression module in Natural Killer cells
| Category | Cell cycle |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes TPX2 (spindle assembly, Aurora A activator), TOP2A (topoisomerase IIa, chromosome decatenation, M-phase), TACC3 (centrosome/spindle), CENPF (kinetochore, G2/M), NUSAP1 (spindle microtubule stabilizer), ASPM (mitotic spindle pole), UBE2C (APC/C ubiquitin ligase, mitotic exit), MKI67 (Ki67, proliferation marker), CKS1B (CDK regulatory subunit, G2/M), KIF22 (kinesin, chromosome segregation), PTTG1 (securin, sister chromatid separation), ARL6IP1 (peripheral). This is a canonical mitotic spindle/M-phase module. Together with M73, M44, M88, and M25, this batch represents a complete cell cycle proliferation program in NK cells, with M41 specifically marking the G2/M mitotic phase.
Genes
ARL6IP1, ASPM, CENPF, CKS1B, KIF22, MKI67, NUSAP1, PTTG1, TACC3, TOP2A, TPX2, UBE2C
Most correlated modules
- G2/M Transition · correlation 0.90
- Replication Histones · correlation 0.84
- Chromatin Remodeling · correlation 0.79
- S-phase Replication · correlation 0.77
- DNA Replication · correlation 0.65
- Replication-Coupled Histones · correlation 0.64
- Histone Variant Remodeling · correlation 0.59
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.